Currently, available options for HA primarily focus on symptomatic management, highlighting a critical need for complementary therapeutic strategies, such as dietary and lifestyle interventions. This review explains recent findings on dietary and nutraceutical interventions, as well as lifestyle modifications such as exercise and rehabilitation programs for HA. It outlines common types of HA, including Friedreich ataxia, spinocerebellar ataxias, ataxia with vitamin E deficiency, ataxia-telangiectasia, and studies on a mixed cohort of patients with HA.
Sunday, April 6, 2025
Dietary and Lifestyle Interventions for the Management of Hereditary Ataxias
Wenyao Yang, Bruce Thompson, Faith Kwa; Front. Nutr. Sec. Nutrition and Metabolism Volume 12 - 2025, doi: 10.3389/fnut.2025.1548821
Friedreich’s ataxia treatment’s sexual dimorphism
Ferreira, J. Friedreich’s ataxia treatment’s sexual dimorphism. Lab Anim 54, 75 (2025). doi:10.1038/s41684-025-01535-2
While NRF2 activation was confirmed in males, no motor or sensory improvements were observed compared to wildtype animals. Female TG+ mice showed no response to the drugs, revealing sexual dimorphism in NRF2 signaling. These results identify early sexual dimorphism in response to treatment and highlight the limitations of NRF2 therapies in the TG+ model and the need for refined approaches in FA treatment development.
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