Journal of Translational Medicine 2011, 9:65 doi:10.1186/1479-5876-9-65
OPEN ACCESS
Wan-Zhang Yang1, Yun Zhang2, Fang Wu1, Min Zhang1, SC Cho3, Chun-Zhen Li1, Shao-Hui Li1, Guo-Jian Shu1, You-Xiang Sheng1, Ning Zhao1, Ying Tang1, Shu Jiang2, Shan Jiang2, Matthew Gandjian4, Thomas E Ichim4* and Xiang Hu2
1 Department of Rehabilitation Medicine, Nanshan Affiliated Hospital of Guangdong Medical College, Shenzhen, China
2 Shenzhen Beike Cell Engineering Research Institution, Shenzhen, China
3 Department of Neurology and Neurosurgery, Stanford University, Stanford, CA, USA
4 Medistem Inc, San Diego, CA, USA
FULL TEXT PDF
Friday, August 26, 2011
The PPAR-gamma agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys
Journal of Neuroinflammation 2011, 8:91 doi:10.1186/1742-2094-8-91
OPEN ACCESS
Christine R Swanson, Valerie Joers, Viktorya Bondarenko, Kevin Brunner, Heather A Simmons, Toni E Ziegler, Joseph W Kemnitz, Jeffrey A Johnson and Marina E Emborg
Activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been proposed as a possible neuroprotective strategy to slow down the progression of early Parkinson's disease (PD). Here we report preclinical data on the use of the PPAR-gamma agonist pioglitazone (Actos(R); Takeda Pharmaceuticals Ltd.) in a paradigm resembling early PD in nonhuman primates.
Clinically, pioglitazone has been tested for Alzheimer disease, multiple sclerosis, autism, stroke, amyotrophic lateral sclerosis, and Friedreich’s Ataxia. The results of these small clinical trials suggest that its administration can benefit patients with neurological disorders.
FULL TEXT PDF
OPEN ACCESS
Christine R Swanson, Valerie Joers, Viktorya Bondarenko, Kevin Brunner, Heather A Simmons, Toni E Ziegler, Joseph W Kemnitz, Jeffrey A Johnson and Marina E Emborg
Activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) has been proposed as a possible neuroprotective strategy to slow down the progression of early Parkinson's disease (PD). Here we report preclinical data on the use of the PPAR-gamma agonist pioglitazone (Actos(R); Takeda Pharmaceuticals Ltd.) in a paradigm resembling early PD in nonhuman primates.
Clinically, pioglitazone has been tested for Alzheimer disease, multiple sclerosis, autism, stroke, amyotrophic lateral sclerosis, and Friedreich’s Ataxia. The results of these small clinical trials suggest that its administration can benefit patients with neurological disorders.
FULL TEXT PDF
Subscribe to:
Posts (Atom)
