Yanjie Li, Yue Lu, Urszula Polak, Kevin Lin, Jianjun Shen, Jennifer Farmer, Lauren Seyer, Angela D. Bhalla, Natalia Rozwadowska, David R. Lynch, Jill Sergesketter Butler and Marek Napierala; Hum. Mol. Genet. (2015) doi: 10.1093/hmg/ddv397, First published online: September 23, 2015
The GAA-induced silencing effect does not influence expression of neighboring genes upstream or downstream of FXN. The results indicate that approaches aimed to reactivate frataxin expression should simultaneously address deficits in transcription initiation and elongation at the FXN locus.
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