We can explain the surprising feature emerging from a detailed analysis of the XANES region of the spectrum, showing that the longer 81-210 frataxin fragment has a smaller propensity for Co2+ binding than the shorter 90-210 one. This fact is explained by the peculiar role of the N-terminal disordered tail in modulating the protein ability to interact with the metal.
Wednesday, June 1, 2022
Metal Ion Binding in Wild-Type and Mutated Frataxin: A Stability Study
Morante, S.; Botticelli, S.; Chiaraluce, R.; Consalvi, V.; La Penna, G.; Novak, L.; et al. (2022); Frontiers. Collection. doi:10.3389/fmolb.2022.878017
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