DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice

J. Clin. Invest. doi:10.1172/JCI39038

Copyright © 2009, The American Society for Clinical Investigation



DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice


Tomoya Terashima1, Kazuhiro Oka1,2, Angelika B. Kritz3, Hideto Kojima2, Andrew H. Baker3 and Lawrence Chan1,2
1Department of Medicine and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA. 3British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.
Address correspondence to: Lawrence Chan, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Phone: (713) 798-4478; Fax: (713) 798-8764; E-mail: lchan@bcm.tmc.edu.



Published June 15, 2009



Full text: http://www.jci.org/articles/view/39038



Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.

Therapeutic Delivery Of A Gene To Dysfunctional Nerves

Therapeutic Delivery Of A Gene To Dysfunctional Nerves

ScienceDaily (June 15, 2009) — In many sensory neuronopathies, painful conditions affecting sensory nerves outside the brain and spinal cord, the affected nerves are in a region known as the DRG. These conditions are difficult to treat. However, researchers have now developed an approach to target therapeutic genes to DRG nerves, and used it to reduce sensory nerve dysfunction in a mouse model of Sandhoff disease, an inherited condition in which many nerves, including those in the DRG, are affected.

Full Text http://www.sciencedaily.com/releases/2009/06/090615171509.htm

Keywords: sensory neuronopathies, painful , DRG, therapeutic genes , dorsal root ganglion , adenoviruses, mice.