Mitochondrial quality control: a matter of life and death for neurons

The EMBO Journal (2012) 31, 1336 - 1349, doi:10.1038/emboj.2012.38

Elena I Rugarli 1,2 and Thomas Langer 2,3,4
1 Institute for Zoology, University of Cologne, Cologne, Germany
2 Center for Molecular Medicine (CMMC) and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany
3 Institute for Genetics, University of Cologne, Cologne, Germany
4 Max-Planck-Institute for Biology of Aging, Cologne, Germany

Keywords: mitochondria, mitochondrial fusion, mitophagy, mitochondrial proteases, neurodegeneration

Monogenic Mitochondrial Disorders

N Engl J Med 2012; 366:1132-1141March 22, 2012

Werner J.H. Koopman, Ph.D., Peter H.G.M. Willems, Ph.D., and Jan A.M. Smeitink, Ph.D.
From the Department of Biochemistry, Nijmegen Center for Molecular Life Sciences (W.J.H.K., P.H.G.M.W.), and the Department of Pediatrics, Nijmegen Center for Mitochondrial Disorders (J.A.M.S.) — both at Radboud University Medical Center, Nijmegen, the Netherlands.

Review Article

The many faces of insulin-like peptide signalling in the brain

Nature Reviews Neuroscience 13, 225-239 (April 2012) | doi:10.1038/nrn3209

Ana M. Fernandez & Ignacio Torres-Alemán

Keywords: insulin-like peptides (ILPs), insulin, insulin-like growth factor 1 (IGF1) and IGF2, brain, regulate energy homeostasis.

Comment: The IGF-1 has been proposed as a possible FA treatment by several researchers, it have even performed a clinical trial proof of concept, the results has been inconclusive because of its short duration and small number of participants