Five markers useful for the distinction of canine mammary malignancy. Karol M Pawlowski, Henryk Maciejewski, Kinga Majchrzak, Izabella Dolka, Jan A Mol, Tomasz Motyl, Magdalena Król. BMC Veterinary Research 2013, 9:138 doi:10.1186/1746-6148-9-138.
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The other selected gene is mipep which is involved in cellular metabolism. The product of this gene performs the final step in processing of nuclear-encoded proteins targeted to the mitochondrial matrix or inner membrane [17]. This gene may contribute to the functional effects of frataxin deficiency and the clinical manifestations of Friedreich ataxia (FA). The exact function of frataxin is still unclear, however it has been implicated in iron homeostasis, protection from oxidative stress and apoptosis [18]. Conflicting results have been reported regarding the role of frataxin in cellular growth: both frataxin knockdown and frataxin overexpression impair cell growth. Despite the role of frataxin in cancer is unknown, the relation between FA and malignancy has been suggested [19].
Thursday, July 11, 2013
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