Structural bases for the interaction of frataxin with the central components of iron–sulphur cluster assembly

Nature Communications, Volume:1, Article number: 95, DOI: doi:10.1038/ncomms1097
Received 08 June 2010, Accepted 22 September 2010, Published 19 October 2010

National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
* Filippo Prischi,
* Clara Iannuzzi,
* Chiara Pastore,
* Salvatore Adinolfi,
* Stephen R. Martin &
* Annalisa Pastore
European Molecular Biology Laboratory, EMBL c/o DESY, Notkestrasse 85, Hamburg D-22603, Germany.
* Petr V. Konarev &
* Dmitri I. Svergun

OPEN ARTICLE

Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H2O2 Signaling

Antioxidants & Redox Signaling. Online Ahead of Print: October 18, 2010, doi:10.1089/ars.2010.3363.
Michel Rigoulet, Edgar D. Yoboue, Anne Devin. Université Bordeaux 2, and Institute of Biochemistry and Genetics of the Cell (IBGC) du CNRS, Bordeaux, France.

Keyworsd: Mitochondria, reactive oxygen species, oxidative stress, respiratory chain, dehydrogenases, bc1 complex, complex I, signaling molecules.

Public summary of opinion on orphan designationN-(6-(2-aminophenylamino)-6-oxohexyl)-4-methylbenzamide for the treatment of Friedreich’s ataxia,

12 October 2010
EMA/COMP/455242/2010
Committee for Orphan Medicinal Products.

On 1 October 2010, orphan designation (EU/3/10/793) was granted by the European Commission to Repligen Europe Limited, Ireland, for N-(6-(2-aminophenylamino)-6-oxohexyl)-4-methylbenzamide for the treatment of Friedreich’s ataxia.