Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases

Dev Dyn. 2010 May;239(5):1529-38. DOI 10.1002/dvdy.22292

Janine Kirstein-Miles, Richard I. Morimoto ^*
Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois

Keywords:  proteostasis, eukaryotic cell,  mitochondria, cellular metabolism, organismal development,  lifespan,  neurodegenerative diseases, Friedreich's ataxia, Parkinson's disease.