OLIGOTHERAPEUTIC STRATEGIES FOR THE TREATMENT OF FRIEDREICH’S ATAXIA. F. Ozsolak, D. Jun Li, D. Parekh, D. Knowlton, M. Wysk, R. Subramanian, J. Barsoum RaNA Therapeutics. Poster 2269T. American Society of Human Genetics (ASHG) 2013 Annual Meeting, Octubre, 22-26, Boston.
KEYWORDS: Friedreich’s ataxia (FRDA), frataxin (FXN), non-coding RNA (ncRNA), oligonucleotide-based therapeutic approaches.
Sunday, September 15, 2013
Rapid DNA Methylation Analysis of the FXN gene in Friedreich
Rapid DNA Methylation Analysis of the FXN gene in Friedreich. S. Al-Mahdawi, C. Sandi, M. A. Pook; Poster 488T. American Society of Human Genetics (ASHG) 2013 Annual Meeting, Octubre, 22-26, Boston.
KEYWORDS: Friedreich ataxia (FRDA), frataxin, epigenetic changes, heterochromatin formation, DNA methylation, GAA repeat, histone acetylation and methylation, specific ‘methylscreen’ restriction enzyme digestion, qPCR-based protocols,. to more rapidly quantify DNA methylation at four of the upstream CpG sites, rapid detection of DNA methylation.
KEYWORDS: Friedreich ataxia (FRDA), frataxin, epigenetic changes, heterochromatin formation, DNA methylation, GAA repeat, histone acetylation and methylation, specific ‘methylscreen’ restriction enzyme digestion, qPCR-based protocols,. to more rapidly quantify DNA methylation at four of the upstream CpG sites, rapid detection of DNA methylation.
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