Positive Preclinical Proof-of-Concept Results of BB-FA in Mice Model of Friedreich’s Ataxia. BioBlast Announced Preclinical Data and Pipeline Updates. April 14, 2015
BioBlast (NasdaqGM: ORPN) announced positive in vitro and in vivo results from a therapy for Friedreich’s ataxia based on the mitochondria-targeting platform, providing support for further clinical development.
Wednesday, April 15, 2015
Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria
Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria. Ken Itoh,, Peng Ye, Tomoh Matsumiya, Kunikazu Tanji, and Taku Ozaki; J Clin Biochem Nutr. 2015 March; 56(2): 91–97. doi: 10.3164/jcbn.14-134
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DNA Topological and Epigenetic Regulation in Neurodevelopment and Disorders
DNA TOPOLOGICAL AND EPIGENETIC REGULATION IN NEURODEVELOPMENT AND DISORDERS . NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE, Project Number: 1K99NS091508-01, Project Leader: TEE, WEE WE, NEW YORK UNIVERSITY SCHOOL OF MEDICINE
PUBLIC HEALTH RELEVANCE: The goal of this project is to gain a mechanistic perspective on the roles of DNA topology and epigenetic regulation in neurodevelopment, and their implications in human neuropsychiatric disorders such as autism, and neurodegenerative diseases such as Freidreich's ataxia.
PUBLIC HEALTH RELEVANCE: The goal of this project is to gain a mechanistic perspective on the roles of DNA topology and epigenetic regulation in neurodevelopment, and their implications in human neuropsychiatric disorders such as autism, and neurodegenerative diseases such as Freidreich's ataxia.
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