Saturday, January 11, 2014

Occurrence of adverse events in chronic intrathecal baclofen infusion: a one-year follow-up study of 158 adults

Occurrence of adverse events in chronic intrathecal baclofen infusion: a one-year follow-up study of 158 adults. Léo Borrini, Djamel Bensmail, Jean-Baptiste Thiebaut, Caroline Hugeron, Célia Rech, Claire Jourdan; Archives of Physical Medicine and Rehabilitation, Available online 6 January 2014. http://dx.doi.org/10.1016/j.apmr.2013.12.019

The objective is to assess the frequency and types of adverse events (AEs) related to intrathecal baclofen (ITB) therapy in adults, and associated risk factors.

Keywords: Baclofen, Implantable pump, Spasticity, Adverse event

MITOCHONDRIA: Mitochondrial OXPHOS (dys) function ex-vivo - the use of primary fibroblasts

MITOCHONDRIA: Mitochondrial OXPHOS (dys) function ex-vivo - the use of primary fibroblasts. Ann Saada, The International Journal of Biochemistry & Cell Biology, Available online 7 January 2014. http://dx.doi.org/10.1016/j.biocel.2013.12.010

Is summarized in this review the usefulness of fibroblasts in culture to verify and study the pathomechanism of new mitochondrial diseases and to evaluate the efficacy of individual treatment options.
The rationale for screening vitamins is that they frequently function as substrates and co-enzymes or as antioxidants and electron donors.