Tuesday, May 18, 2010

Neuroprotective Multifunctional Iron Chelators: From Redox-Sensitive Process to Novel Therapeutic Opportunities

Antioxidants & Redox Signaling. Ahead of print. doi:10.1089/ars.2009.2929.
Online Ahead of Print: May 17, 2010

Orly Weinreb, Tamar Amit, Silvia Mandel, Lana Kupershmidt, Moussa B.H. Youdim. 
Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion-Faculty of Medicine, Haifa, Israel.

Keywords:  cytotoxic signals,   neurodegenerative brain, oxidative stress, inflammation, accumulation of iron,  iron chelators,  hydroxyl radical formation,  Fenton reaction, hypoxia-inducible factor-1α (HIF-1α), prolyl-4-hydroxylases (PHDs).