Our findings shed light on cellular changes caused by FXN downregulation in cerebellar astrocytes, likely impairing their complex interaction with neurons. The potentially impaired ability to provide neuronal cells with glutathione or to release neuromodulators in a calcium-dependent manner could affect neuronal function, contributing to neurodegeneration.
Thursday, December 12, 2024
Altered calcium responses and antioxidant properties in Friedreich's ataxia-like cerebellar astrocytes
Marullo, Chiara & Croci, Laura & Giupponi, Iris & Rivoletti, Claudia & Zuffetti, Sofia & Bettegazzi, Barbara & Cremona, Ottavio & Giunti, Paola & Ambrosi, Alessandro & Casoni, Filippo & Consalez, Gian & Codazzi, Franca. (2024). Altered calcium responses and antioxidant properties in Friedreich's ataxia-like cerebellar astrocytes. Journal of cell science. 10.1242/jcs.263446.
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