Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production.

Neurobiol Aging. 2010 Jul 29.

Wu Z, Du Y, Xue H, Wu Y, Zhou B.
State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University, Beijing 100084, China.

I would like to emphasize: .../... "suggesting Friedreich's ataxia patients might be more susceptible to Al toxicity".../...

A rapid, noninvasive immunoassay for frataxin: Utility in assessment of Friedreich ataxia.

Mol Genet Metab. 2010 Jul 8. [Epub ahead of print]

Deutsch EC, Santani AB, Perlman SL, Farmer JM, Stolle CA, Marusich MF, Lynch DR.
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Keywords: Friedreich ataxia (FRDA), frataxin, Western blot analysis, fibroblasts, lymphocytes, , muscle biopsies, lateral flow immunoassay, buccal cells.