Thursday, July 28, 2011

The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases

Stem Cell Research & Therapy 2011, 2:32 doi:10.1186/scrt73, Published: 28 July 2011

Jun Peng and Xianmin Zeng

Keywords: Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Friedreich's ataxia, neurodegenerative diseases, no effective clinical therapies, human adult somatic cells, induced pluripotent stem cells (iPSCs), in vitro disease mechanism study, in vivo cell replacement therapy.

A pilot trial of deferiprone for neurodegeneration with brain iron accumulation.

Haematologica. 2011 Jul 26. [Epub ahead of print]

Abbruzzese G, Cossu G, Balocco M, Marchese R, Murgia D, Melis M, Galanello R, Barella S, Matta G, Ruffinengo U, Bonuccelli U, Forni GL.

(Clinicaltrials.gov identifier: NTC00907283.)

Keywords: Deferiprone, Friedreich's ataxia, cerebral iron accumulation, pantothenate kinase-associated neurodegeneration, parkinsonism and focal dystonia, Magnetic resonance imaging, neurological examinations, Chelation treatment.