Deficiency in frataxin homologue YFH1 in the yeast Pichia guilliermondii leads to missregulation of iron acquisition and riboflavin biosynthesis and a

Biometals. 2009 Aug 1.

Deficiency in frataxin homologue YFH1 in the yeast Pichia guilliermondii leads to missregulation of iron acquisition and riboflavin biosynthesis and affects sulfate assimilation.

Pynyaha YV, Boretsky YR, Fedorovych DV, Fayura LR, Levkiv AI, Ubiyvovk VM, Protchenko OV, Philpott CC, Sibirny AA.

Institute of Cell Biology, NAS of Ukraine, Drahomanov Street 14/16, 79005, Lviv, Ukraine.

Keyword: riboflavin, YFH1, frataxin homologue, iron, impaired sulfate assimilation, hypersensitivity to hydrogen peroxide, superoxide dismutase.

Frataxin, an iron taxi on the road to cellular Fe–S bioassembly

Traffic and storage of metal ions, J Biol Inorg Chem (2009) 14 (Suppl 1):S53–S56 (Oral Presentation)
G-08
Frataxin, an iron taxi on the road to cellular Fe–S bioassembly
Timothy L. Stemmler
Department of Biochemistry and Molecular Biology, Wayne State
University, School of Medicine, Detroit, MI 48201 USA.
tstemmle@med.wayne.edu

http://www.springerlink.com/content/8x412685h746427g/fulltext.pdf

Keywords: Friedreich’s ataxia, iron homeostasis, iron overload, oxidative stress, mitochondrial DNA stability, iron–sulfur protein, iron chaperone, acidic residues, Fe–S cluster assembly enzyme (Isu),