Friedreich Ataxia Global Clinical Trials Review, H1, 2013

Friedreich Ataxia Global Clinical Trials Review, H1, 2013.

This report provides elemental information and data relating to the clinical trials on Friedreich Ataxia. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe.

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy.

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy. Chowdhury SK, Smith DR, Fernyhough P; Neurobiology of Disease [2013, 51:56-65]

The role of mitochondrial dysfunction in the etiology of diabetic neuropathy is compared with other types of neuropathy with a distal dying-back pathology such as Friedreich ataxia, Charcot-Marie-Tooth disease type 2 .....

Rating disease progression of Friedreich’s ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database

Rating disease progression of Friedreich’s ataxia by the International Cooperative Ataxia Rating Scale: analysis of a 603-patient database . Günther Metz, Nicholas Coppard, Jonathon M. Cooper, Martin B. Delatycki, Alexandra Dürr, Nicholas A. Di Prospero, Paola Giunti, David R. Lynch8, J. B. Schulz, Christian Rummey and Thomas Meier. Brain (2013) 136 (1): 259-268. doi: 10.1093/brain/aws309

Keywords: cross-sectional study, disease progression in Friedreich’s ataxia, International Cooperative Ataxia Rating Scale, function of disease duration, age of onset, GAA repeat lengths.

Subvention importante

Subvention importante . CAFA, Canadian Association for Familial Ataxias - Claude St-Jean Foundation.

Professor Jacques P. Tremblay and his team at the CHUL laboratory in Quebec has just received a grant of $ 160,000 from the Canadian Institutes of Health Research (CIHR) for the project of inducing the production of frataxin with TALE-VP64 targeting the promoter of this protein. This will help to intensify research on Friedreich's ataxia.

Magnetic Resonance Imaging and Spectroscopy of the Central Nervous System in Friedreich's Ataxia

Magnetic Resonance Imaging and Spectroscopy of the Central Nervous System in Friedreich's Ataxia.

University of Minnesota - Clinical and Translational Science Institute

ClinicalTrials.gov Identifier: NCT01776164
First received: January 14, 2013
Last updated: January 22, 2013
Last verified: January 2013



.../... the investigators aim at utilizing the capabilities of Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS). Using techniques called Diffusion Imaging, resting-state functional MRI, and Proton Spectroscopy (1H MRS), the investigators propose to determine the differences in the connectivity and neurochemistry of the spinal cord and the brain .../...