Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPAR{gamma} pathway as a therapeutic target

Hum Mol Genet. 2009 Apr 17. [Epub ahead of print]
Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPAR{gamma} pathway as a therapeutic target in Friedreich's ataxia.
Coppola G, Marmolino D, Lu D, Wang Q, Cnop M, Rai M, Acquaviva F, Cocozza S, Pandolfo M, Geschwind DH.
Program in Neurogenetics, Department of Neurology David Geffen School of Medicine, University of California at Los Angeles, CA 90095.

OPEN ACCESS:

http://hmg.oxfordjournals.org/cgi/content/full/18/13/2452

http://hmg.oxfordjournals.org/cgi/reprint/18/13/2452.pdf

Brain iron homeostasis and neurodegenerative disease

Citation:

Neurology, Vol. 72, Issue 16, 1436-1440, April 21, 2009
CLINICAL IMPLICATIONS OF NEUROSCIENCE RESEARCH

Brain iron homeostasis and neurodegenerative disease
Eduardo E. Benarroch

Article topics:
Physiology..Transferrin
Medicine..Genes
Medicine..Iron Metabolism
Cell Biology..Endothelial Cells
Physiology..Homeostasis
Medicine..Gene Expression
Medicine..Genetics
Medicine..Neurodegenerative Diseases
Medicine..Cardiovascular Genetics
Biochemistry..Ferritin
Medicine..Friedreich Ataxia
Biochemistry..Pantothenate Kinase
Cell Biology..Astrocytes
Biochemistry..Kinases
Medicine..Ataxia

http://www.neurology.org/cgi/content/citation/72/16/1436?rss=1