Pharmacokinetic evaluation of idebenone.

Expert Opin Drug Metab Toxicol. 2010 Nov;6(11):1437-44.

Becker C, Bray-French K, Drewe J.
Basel Pharmacoepidemiology Unit, University Hospital Basel, Switzerland.

Conclusions: Idebenone shows dose-proportional pharmacokinetics in healthy subjects in daily doses up to 2250 mg, and was safe and well tolerated at doses up to 2250 mg/day, in clinical studies.

Pathogenesis of impaired glucose tolerance and diabetes in Friedreich's ataxia: contribution of insulin resistance and pancreatic beta cell dysfunction.

The free library,
Miriam Cnop, MD, PhD, Universite Libre de Bruxelles, Brussels, Belgium

Research summary

Keywords: pancreatic b cells, Friedreich's ataxia, insulin demand.