J Biol Chem. 2009 Jun 19.
Przemyslaw W, Vaarmann A, Choubey V, Safiulina D, Liiv J, Kuum M, Kaasik A.
Department of Pharmacology, University of Tartu, Estonia.
Link to full text: http://www.jbc.org/cgi/reprint/M109.018911v1?view=long&pmid=19542216
Keywords: PGC-1[alpha], PGC-1[beta, peroxisome-proliferator-activated receptor gamma coactivator-1a, mitochondrial biogenesis , cellular energy metabolism , muscle, liver, neurons, activates transcriptional activity of PGC-1[alpha] in neurons, compensate neuronal mitochondrial loss , treating neurodegenerative diseases , mitochondrial dysfunction , oxidative damage.
Friday, June 26, 2009
Antidepressant directly stimulates brain growth factor receptors
PHYSORG.COM, June 25th, 2009
The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown.
Other sources:
http://www.sciencedaily.com/releases/2009/06/090625133059.htm
http://www.eurekalert.org/pub_releases/2009-06/eu-ads062209.php
The widely used antidepressant and pain medication amitriptyline--but not other closely related drugs -- can impersonate the brain's own growth factors, researchers at Emory University School of Medicine have shown.
Other sources:
http://www.sciencedaily.com/releases/2009/06/090625133059.htm
http://www.eurekalert.org/pub_releases/2009-06/eu-ads062209.php
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