Abnormal Left Atrial Contraction in Friedreich Ataxia—Relation with Both Alleles of the FXN Gene

Heart, Lung and Circulation
Volume 18, Supplement 3, 2009, Page S15
Abstracts for the Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research, Australasian Section, Annual Scientific Meeting

R.E. Peverill^1, , L. Donelan¹, J.S. Gelman¹, P.M. Mottram¹, L.A. Corben² and M.B. Delatycki²

¹Monash Cardiovascular Research Centre, MonashHEART and Monash University Department of Medicine (MMC), Australia

²Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Australia

The role of PGC-1{alpha} on mitochondrial function and apoptotic susceptibility in muscle

Peter J. Adhihetty,² Giulia Uguccioni,^1,3 Lotte Leick,⁴ Juan Hidalgo,⁵ Henriette Pilegaard,⁴ and David A. Hood^1,2,3

¹School of Kinesiology and Health Science, ²Department of Biology, and ³The Muscle Health Research Centre, York University, Toronto, Ontario, Canada; ⁴Copenhagen Muscle Research Centre and Centre of Inflammation and Metabolism, Department of Biology, University of Copenhagen, Denmark, and ⁵Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Autonomous University of Barcelona, Barcelona, Spain

Submitted 12 February 2009 ; accepted in final form 5 May 2009

Keywords: endurance training; exercise; mitochondrial biogenesis; reactive oxygen species, cytochrome-c oxidase activity, brain, liver, pancreas.