Reisman SA, Gahir SS, Lee CY, Proksch JW, Sakamoto M, Ward KW (Reata Pharmaceuticals, Inc., Irving, TX 75063, USA); Drug Des Devel Ther. 2019; 13: 1259–1270.Published online 2019 Apr 17. doi: 10.2147/DDDT.S193889
Overall, the monkey data demonstrate a well-characterized and dose-proportional PK and tissue distribution profile after oral administration of omaveloxolone, which was associated with Nrf2 activation. Further, systemic exposures to omaveloxolone that produce Nrf2 activation in monkeys were readily achievable in Friedreich's ataxia patients after oral administration.
Tuesday, June 11, 2019
Is left ventricular longitudinal strain a good prognostic factor in Friedreich ataxia?
C. Heuze, L. Legrand, A. Diallo, M.L. Monin, C. Ewenczyk, R. Isnard, E. Vicaut, A. Durr, F. Pousset, Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 3, 2019, Page e321, doi:10.1016/j.acvdsp.2019.04.036.
GLS is a predictor of morbimortality but is not superior to LVEF in FRDA patients.
GLS is a predictor of morbimortality but is not superior to LVEF in FRDA patients.
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