Debkumar Pain, Andrew Dancis, Current Opinion in Genetics & Development, Volume 38, June 2016, Pages 45-51, ISSN 0959-437X, doi:10.1016/j.gde.2016.03.006.
Impairment of Fe–S cluster assembly creates diseases in diverse and surprising ways: the loss of function of lipoic acid synthase, the heme biosynthetic pathway in red cell precursors is specifically targeted and tRNA modifications arising from action of the cysteine desulfurase and/or Fe–S cluster proteins are lost. These defects can then result in cancer, neurologic dysfunction or type 2 diabetes.
Monday, April 11, 2016
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