Neuroimaging Biomarkers for Friedreich Ataxia: A Cross-Sectional Analysis of the TRACK-FA Study

Georgiou-Karistianis, N., Corben, L.A., Lock, E.F., Bujalka, H., Adanyeguh, I., Corti, M., Deelchand, D.K., Delatycki, M.B., Dogan, I., Farmer, J., França, M.C., Jr., Gabay, A.S., Gaetz, W., Harding, I.H., Joers, J., Lax, M.A., Li, J., Lynch, D.R., Mareci, T.H., Martinez, A.R.M., Pandolfo, M., Papoutsi, M., Parker, R.G., Reetz, K., Rezende, T.J.R., Roberts, T.P., Romanzetti, S., Rudko, D.A., Saha, S., Schulz, J.B., Subramony, S.H., Supramaniam, V.G., Lenglet, C. and Henry, P.-G. (2025), Neuroimaging Biomarkers for Friedreich Ataxia: A Cross-Sectional Analysis of the TRACK-FA Study. Ann Neurol. doi: 10.1002/ana.27237

 Our findings provide strong imaging evidence of impaired development of spinal cord and superior cerebellar peduncles during childhood in Friedreich ataxia and open the way for the use of neuroimaging biomarkers in clinical trials.