Tandem Repeat Modification during Double-Strand Break Repair Induced by an Engineered TAL Effector Nuclease in Zebrafish Genome

Tandem Repeat Modification during Double-Strand Break Repair Induced by an Engineered TAL Effector Nuclease in Zebrafish Genome. Huang W, Zheng J, He Y, Luo, PLoS ONE 8(12): e84176. doi:10.1371/journal.pone.0084176

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Dysphagia and swallowing-related quality of life in Friedreich ataxia

Dysphagia and swallowing-related quality of life in Friedreich ataxia. Adam P. Vogel, Sophie E. Brown, Joanne E. Folker, Louise A. Corben, Martin B. Delatycki;
Journal of Neurology, December 2013. DOI 10.1007/s00415-013-7208-4

Keywords: Dysphagia, Friedreich ataxia (FRDA), quality of life, oral-motor examination, speech and swallowing, incoordination, weakness, spasticity.

Role of Frataxin, a Protein Implicated in Friedreich Ataxia, in Making Iron-Sulfur Clusters

Role of Frataxin, a Protein Implicated in Friedreich Ataxia, in Making Iron-Sulfur Clusters. The Journal of Biological Chemistry, 288, 36787. December 27, 2013; 10.1074/jbc.P113.525857

The authors concluded that their work “may help develop a drug for treating Friedreich ataxia associated with frataxin deficiency.”

See referenced article: Frataxin Directly Stimulates Mitochondrial Cysteine Desulfurase by Exposing Substrate-binding Sites, and a Mutant Fe-S Cluster Scaffold Protein with Frataxin-bypassing Ability Acts Similarly. J. Biol. Chem. 2013, 288, 36773–36786.