Sara Nguyen, Neil Wilson, Darko Stefanovski, G. Maria Gur, Anna Dedio, Kristin Wade, David Lynch, Ravinder Reddy, Andrea Kelly, Michael Rickels, Shana McCormack; Journal of the Endocrine Society, Volume 3, Issue Supplement_1, April-May 2019, MON–LB030, doi:10.1210/js.2019-MON-LB030
Individuals with a genetic mitochondrial disorder conferring increased diabetes risk have decreased whole body insulin sensitivity that may be mediated by decreased skeletal muscle OXPHOS capacity. Studies in rare disorders may provide insights into the role of skeletal muscle metabolism in the pathogenesis of Type 2 diabetes.
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