Human ISD11 is essential for both iron–sulfur cluster assembly and maintenance of normal cellular iron homeostasis

Human Molecular Genetics Advance Access originally published online on May 18, 2009
Human Molecular Genetics 2009 18(16):3014-3025; doi:10.1093/hmg/ddp239
Published by Oxford University Press 2009

Yanbo Shi, Manik C. Ghosh, Wing-Hang Tong and Tracey A. Rouault^*

National Institute of Child Health and Human Development, Molecular Medicine Program, Bethesda, MD 20892, USA

^* To whom correspondence should be addressed. Tel: +1 301 496 6368; Fax: +1 301 402 0078; Email: trou@helix.nih.gov

Keywords: iron–sulfur (Fe–S) cluster biogenesis, Saccharomyces cerevisiae, cysteine desulfurase (ISCS), mitochondrial compartment, inactivated mitochondrial and cytosolic aconitases, iron regulatory protein 1, iron regulatory protein 2, punctate ferric iron accumulations in cells, iron homeostasis.