Frataxins Emerge as New Players of the Intracellular Antioxidant Machinery

Uceda, A.B.; Donoso, J.; Frau, J.; Vilanova, B.; Adrover, M.; Antioxidants 2021, 10, 315. doi:10.3390/antiox10020315 

Consequently, our work proves that Yfh1 and Hfra are essential components of the intracellular antioxidant machinery, not only because they are able to regulate the detoxifying enzymatic mechanisms, but also because they directly act against the production of ROS. This latter mechanism also has further consequences since both proteins are able to unspecifically inhibit the oxidation of α-syn, which prove that they could act as molecular shields to protect a broad set of intracellular oxidation-prone proteins.