Saturday, April 6, 2013

Mitochondrial Diseases of the Brain

Mitochondrial Diseases of the Brain. Rajnish K. Chaturvedi, M. Flint Beal; Free Radical Biology and Medicine, Available online 6 April 2013.
http://dx.doi.org/10.1016/j.freeradbiomed.2013.03.018

Keywords: Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, Friedreich’s ataxia, Neurodegenerative diseases, Mitochondrial dysfunction, Creatine, Co-Q10, PGC-1α, Sirtuins.

Moving Forward on Shifting Sands: Ethical Regulation of Gene Therapy Clinical Trials in the United Kingdom

Moving Forward on Shifting Sands: Ethical Regulation of Gene Therapy Clinical Trials in the United Kingdom. Emma Morris, Martin Gore, Andrew Baker and Adrian J Thrasher; Molecular Therapy (2013); 21 4, 715–716. doi:10.1038/mt.2013.43

Editorial. FULL TEXT

Gene Therapy Researchers' Assessments Of Risks And Perceptions Of Risk Acceptability In Clinical Trials

Gene Therapy Researchers' Assessments Of Risks And Perceptions Of Risk Acceptability In Clinical Trials. Claire T. Deakin, Ian E. Alexander, Cliff A. Hooker, Ian H. Kerridge; Molecular Therapy (2013); 21 4, 806–815. doi:10.1038/mt.2012.230

Decisions about clinical trials appear to be influenced not only by the clinical context and preclinical evidence. Identifying moral assumptions and qualitative assessments underpinning the design and conduct of research may facilitate future decision-making in clinical trials.