Hum. Mol. Genet. (2012) doi: 10.1093/hmg/dds110 First published online: March 23, 2012
Barbara Tomassini1, Gaetano Arcuri1, Silvia Fortuni1, Chiranjeevi Sandi2, Vahid
Ezzatizadeh2, Carlo Casali3, Ivano Condò1, Florence Malisan1, Sahar Al-Mahdawi2,
Mark Pook2 and Roberto Testi1
1 Laboratory of Immunology and Signal Transduction, University of Rome “Tor
Vergata”, 00133 Rome, Italy
2 Division of Biosciences, School of Health Sciences and Social Care, Brunel University,
Uxbridge, UB8 3PH, UK
3 Department of Neurology, University of Rome “La Sapienza”, Polo Pontino, 04100
Latina, Italy
Importantly,in vivo treatment with IFN increases frataxin expression in DRG neurons, prevents their pathological changes and ameliorates the sensorimotor performance in FRDA mice. These results disclose new roles for IFN in cellular metabolism and have direct implications for the treatment of FRDA.
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