Frataxin is always present in all eukaryotes, it seems essential to life, surprisingly in this paper describes an organism that lacks frataxin, perhaps a more detailed study of this protist would give clues to understand the frataxin function, and help to understand their relationship with the Fe-S clusters.
PLoS ONE 6(2): e17285. doi:10.1371/journal.pone.0017285
Petr L. Jedelský1,2, Pavel Doležal1, Petr Rada1, Jan Pyrih1, Ondřej Šmíd1, Ivan Hrdý1, Miroslava Šedinová1, Michaela Marcinčiková1, Lubomír Voleman1, Andrew J. Perry3, Neritza Campo Beltrán1, Trevor Lithgow3, Jan Tachezy1*
1 Department of Parasitology, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 2 Laboratory of Mass Spectrometry, Faculty of Science, Charles University in Prague, Prague, Czech Republic, 3 Department of Biochemistry & Molecular Biology, Monash University, Clayton Campus, Melbourne, Australia
A striking deviation from other eukaryotes is the absence of frataxin in Giardia mitosomes. Frataxin is invariably present in eukaryotes that contain the ISC-type FeS cluster assembly machinery.
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Friday, February 25, 2011
Lu AA24493 - Expected report data of clinical phase II
Lu AA24493 (novel carbamoylated form of human erythropoietin (EPO)) is in clinical phase II in the treatment of Friedreich's ataxia and in clinical phase I in the treatment of acute ischaemic stroke. Ongoing studies in both programmes are expected to report data in the first half of 2011.
Regulation of cellular iron metabolism
Biochem. J. (2011) 434 (365–381)
Jian Wang*† and Kostas Pantopoulos*†‡1
*Department of Biochemistry, University of Texas Southwestern Medical Center, U.S.A. †Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Canada.
‡Department of Medicine, McGill University, Canada
Keywords: frataxin, ferritin, ferroportin, iron-regulatory protein 1 (IRP1), iron-regulatory protein 2 (IRP2), iron–sulfur cluster (ISC), transferrin receptor (TfR).
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Jian Wang*† and Kostas Pantopoulos*†‡1
*Department of Biochemistry, University of Texas Southwestern Medical Center, U.S.A. †Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital, Canada.
‡Department of Medicine, McGill University, Canada
Keywords: frataxin, ferritin, ferroportin, iron-regulatory protein 1 (IRP1), iron-regulatory protein 2 (IRP2), iron–sulfur cluster (ISC), transferrin receptor (TfR).
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