Wednesday, February 22, 2012

Biochemical Characterization of Iron-Sulfur Cluster Assembly in the Scaffold IscU of Escherichia coli.

Biochemistry (Mosc). 2012 Feb;77(2):135-42.

Wu G, Li L.
College of Life Science, Zhejiang University, Hangzhou, 310058, China.

Keywords: Iron-sulfur cluster, IscU, iron, cysteine, environmental pH, IscS, first order reaction, mixed order reaction, zero order reaction, apo-IscU.

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Effector role reversal during evolution: the case of frataxin in Fe-S cluster biosynthesis

Biochemistry, Just Accepted Manuscript, DOI: 10.1021/bi201628j, Publication Date (Web): February 21, 2012

Jennifer Bridwell-Rabb, Clara Iannuzzi, Annalisa Pastore, and David P. Barondeau

Keywords: frataxin (FXN), Friedreich’s ataxia, NFS1-ISD11-ISCU2-FXN (SDUF) core Fe-S assembly complex, cysteine desulfurase, Fe-S cluster biosynthesis.

Cognition in Friedreich Ataxia.

Cerebellum. 2012 Feb 16.

Nieto A, Correia R, de Nóbrega E, Montón F, Hess S, Barroso J.
School of Psychology, University of La Laguna, 38205, La Laguna, Tenerife, Spain,

Keywords: Friedreich ataxia (FRDA), cognitive status, motor problems, processing speed, attention, working memory, executive functions, verbal and visual memory, visuoperceptive and visuospatial skills, visuoconstructive functions, language, depression inventory, executive problems, parieto-temporal dysfunction, mild anomalies in cerebral hemispheres, cerebro-cerebellar circuits..

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

PLoS Biol 10(2): e1001257. doi:10.1371/journal.pbio.1001257

Kim Debacker#, Aisling Frizzell#, Olive Gleeson, Lucy Kirkham-McCarthy, Tony Mertz, Robert S. Lahue*
Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland

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Currently some researchers and pharmaceutical labs are testing HDACi for relief of the transcription-related consequences of expansions in triplet expansion diseases, they may also have the beneficial side effect of reducing the risk of further somatic expansion.

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