Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

PLoS Biol 10(2): e1001257. doi:10.1371/journal.pbio.1001257

Kim Debacker#, Aisling Frizzell#, Olive Gleeson, Lucy Kirkham-McCarthy, Tony Mertz, Robert S. Lahue*
Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland Galway, Galway, Ireland

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Currently some researchers and pharmaceutical labs are testing HDACi for relief of the transcription-related consequences of expansions in triplet expansion diseases, they may also have the beneficial side effect of reducing the risk of further somatic expansion.

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