Cyrielle Coignion, Cyril Goizet, Xavier Vandamme, Revue Neurologique, Volume 172, Supplement 1, April 2016, Page A124, ISSN 0035-3787, doi:10.1016/j.neurol.2016.01.293.
L’atteinte cardiaque serait responsable de 59 % des décès chez ces patients. L’idébénone pourrait avoir un effet protecteur en améliorant la fonction cardiaque. L’association maladie de Friedreich et accidents vasculaires cérébraux est possible par le biais d’une cardiomyopathie hypertrophique et d’une FA qu’il est nécessaire de dépister afin de mettre en place un traitement cardioprotecteur.
Saturday, March 19, 2016
Both idebenone and idebenol are localized near the lipid-water interface of the membrane and increase its fluidity
Victoria Gómez-Murcia, Alejandro Torrecillas, Ana M. de Godos, Senena Corbalán-García, Juan C. Gómez-Fernández, Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1858, Issue 6, June 2016, Pages 1071-1081, ISSN 0005-2736, doi:10.1016/j.bbamem.2016.02.034.
"Idebenone is an interesting drug but care should be taken in calling it a coenzyme Q analogue."
Idebenone is sometimes assumed to be an analog of ubiquinone, although their way of interaction with the components of the electron transport chain in mitochondria differs. Whereas ubiquinone-10 carries electrons from complex I and complex II to complex III, idebenone receives electrons from complex I. idebenone shares with ubiquinone the same quinone group, it might also be expected to act as a potent antioxidant, although other studies do not exclude the idea that idebenone may detoxify ROS in a different way to ubiquinone. Since idebenone and idebenol have similar locations, this may explain why this pair does not play exactly the same role as the couple ubiquinone-10/ubiquinol-10 in the mitochondria.
"Idebenone is an interesting drug but care should be taken in calling it a coenzyme Q analogue."
Idebenone is sometimes assumed to be an analog of ubiquinone, although their way of interaction with the components of the electron transport chain in mitochondria differs. Whereas ubiquinone-10 carries electrons from complex I and complex II to complex III, idebenone receives electrons from complex I. idebenone shares with ubiquinone the same quinone group, it might also be expected to act as a potent antioxidant, although other studies do not exclude the idea that idebenone may detoxify ROS in a different way to ubiquinone. Since idebenone and idebenol have similar locations, this may explain why this pair does not play exactly the same role as the couple ubiquinone-10/ubiquinol-10 in the mitochondria.
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