Transplanted Neurons Develop Disease-like Pathology In Huntington's Patients

ScienceDaily (July 20, 2009) — The results of a recent study published in the Proceedings of the National Academy of Sciences question the long-term effects of transplanted cells in the brains of patients suffering from Huntington's disease.

Other source: http://www.eurekalert.org/pub_releases/2009-07/ul-tnd071609.php

Original work which explains the test:

Transplanted fetal striatum in Huntington's disease: Phenotypic development and lack of pathology

Thomas B. Freeman,^abcde Francesca Cicchetti,^df Robert A. Hauser,^bcg Terrence W. Deacon,^f Xiao-Jiang Li,^h Steven M. Hersch,ⁱ G. Michael Nauert,^j Paul R. Sanberg,^abc Jeffrey H. Kordower,^k Samuel Saporta,^acl and Ole Isacson^ef

^aDepartment of Neurosurgery,^bDepartment of Pharmacology and Experimental Therapeutics, and, ^cThe Neuroscience Program, University of South Florida, Tampa, FL 33606; Departments of, ^gNeurology and, ^lAnatomy,^jWomen's Center, Tampa, FL 33606;^kDepartment of Neurological Sciences, Rush Presbyterian Medical Center, Chicago, IL 60612;^fNeuroregeneration Laboratory, McLean Hospital/MGH, Harvard Medical School, Belmont, MA 62478; and Departments of, ^hGenetics and, ⁱNeurology, Emory University, Atlanta, GA 30322

^dT.B.F. and F.C. contributed equally to this work.

^eTo whom reprint requests should be addressed: T.B.F. (phone: 813-259-0889; fax: 813-259-0944; E-mail: tfreeman@com1.med.usf.edu) or O.I. (E-mail: isacson@helix.mgh.harvard.edu).

Edited by Solomon H. Snyder, Johns Hopkins University School of Medicine, Baltimore, MD, and approved October 12, 2000

Received July 13, 2000.