The treatment was well tolerated by most patients, and only some of them experienced minor adverse effects at the beginning of the trial. Conclusion: Calcitriol dosage used (0.25mcg/24h) is safe for FRDA patients and it increases frataxin levels. We cannot rule out that higher doses administered longer could yield neurological benefits.
Monday, October 30, 2023
Calcitriol treatment is safe and increases frataxin levels in Friedreich Ataxia patients
Calcitriol treatment is safe and increases frataxin levels in Friedreich Ataxia patients. Berta Alemany-Perna, Jordi Tamarit, Daniel Lopez Dominguez, Anna Quiroga-Varela, Miguel Merchan-Ruiz, Lluis Ramio Torrenta, David Genis Batlle, Joaquim Ros; medRxiv 2023.10.28.23297713; doi:10.1101/2023.10.28.23297713
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