Genes & Development, Received May 29, 2009, Accepted August 7, 2009.
Nan Wu, Lei Yin, Elyisha A. Hanniman, Shree Joshi and Mitchell A. Lazar
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Keywords: Intracellular heme levels, mitochondrial respiration, iron toxicity, negative feedback mechanism, nuclear heme receptor, Rev-erbα, NCoR/histone deacetylase 3 (HDAC3), coactivator PGC-1α, heme synthesis, cellular energy metabolism.
Wednesday, September 16, 2009
Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise.
Curr Pharm Des. 2009 Sep 15:Antonello-Mai
Rotili D, Valente S, Kazantsev AG.
Harvard Medical School, Massachusetts General Hospital, CNY114 16th, Street, Charlestown, MA 02129, USA. akazantsev@partners.org.
Keywords: Neurodegenerative disorders (NDs), Huntington's disease, Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's ataxia, pathologic phenotype, acetylation homeostasis, histone acetyltransferase (HAT), histone deacetylase (HDAC) , recent applications, HDAC inhibitors, HDAC/SIRT, CNS pathologies.
Rotili D, Valente S, Kazantsev AG.
Harvard Medical School, Massachusetts General Hospital, CNY114 16th, Street, Charlestown, MA 02129, USA. akazantsev@partners.org.
Keywords: Neurodegenerative disorders (NDs), Huntington's disease, Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's ataxia, pathologic phenotype, acetylation homeostasis, histone acetyltransferase (HAT), histone deacetylase (HDAC) , recent applications, HDAC inhibitors, HDAC/SIRT, CNS pathologies.
Human Ind1, an iron-sulfur cluster assembly factor for respiratory complex I.
Mol Cell Biol. 2009 Sep 14.
Sheftel AD, Stehling O, Pierik AJ, Netz DJ, Kerscher S, Elsässer HP, Wittig I, Balk J, Brandt U, Lill R.
Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, 35033 Marburg, Germany; Goethe-Universität, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Cluster of Excellence "Macromolecular Complexes", 60590 Frankfurt am Main, Germany; Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.
Keywords: Respiratory complex I, NADH:ubiquinone oxidoreductase, iron-sulfur (Fe/S) clusters, mitochondrial diseases, Fe/S cofactors, huInd1, HeLa cells, RNAi technology, NDUFS1, NDUFV1, NDUFS3, NDUFA13, radiolabelling technique, iron.
Sheftel AD, Stehling O, Pierik AJ, Netz DJ, Kerscher S, Elsässer HP, Wittig I, Balk J, Brandt U, Lill R.
Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, 35033 Marburg, Germany; Goethe-Universität, Zentrum der Biologischen Chemie, Molekulare Bioenergetik, Cluster of Excellence "Macromolecular Complexes", 60590 Frankfurt am Main, Germany; Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK.
Keywords: Respiratory complex I, NADH:ubiquinone oxidoreductase, iron-sulfur (Fe/S) clusters, mitochondrial diseases, Fe/S cofactors, huInd1, HeLa cells, RNAi technology, NDUFS1, NDUFV1, NDUFS3, NDUFA13, radiolabelling technique, iron.
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