Wednesday, September 16, 2009

Histone Deacetylase Inhibitors and Neurodegenerative Disorders: Holding the Promise.

Curr Pharm Des. 2009 Sep 15:Antonello-Mai

Rotili D, Valente S, Kazantsev AG.
Harvard Medical School, Massachusetts General Hospital, CNY114 16th, Street, Charlestown, MA 02129, USA. akazantsev@partners.org.

Keywords: Neurodegenerative disorders (NDs), Huntington's disease, Alzheimer's disease, Parkinson disease, amyotrophic lateral sclerosis, spinal muscular atrophy, Friedreich's ataxia,  pathologic phenotype,   acetylation homeostasis,  histone acetyltransferase (HAT),  histone deacetylase (HDAC) , recent applications, HDAC inhibitors, HDAC/SIRT, CNS pathologies.

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