Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbα

Genes & Development, Received May 29, 2009, Accepted August 7, 2009.

Nan Wu, Lei Yin, Elyisha A. Hanniman, Shree Joshi and Mitchell A. Lazar

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA

Keywords: Intracellular heme levels, mitochondrial respiration, iron  toxicity, negative feedback mechanism,  nuclear heme receptor, Rev-erbα,  NCoR/histone deacetylase 3 (HDAC3),  coactivator PGC-1α, heme synthesis, cellular energy metabolism.