PGC‐1α protects from myocardial ischaemia‐reperfusion injury by regulating mitonuclear communication

Li, Y‐Q, Jiao, Y, Liu, Y‐N, Fu, J‐Y, Sun, L‐K, Su, J.; J Cell Mol Med. 2021; 00: 1‐ 8. doi:10.1111/jcmm.16236 In this review, we speculate the role of PGC‐1α as a key regulator of mitonuclear communication, which may interacts with nuclear factor, erythroid 2 like ‐1 and ‐2 (NRF‐1/2) to inhibit mitochondrial oxidative stress, promote the clearance of damaged mitochondria, enhance mitochondrial biogenesis, and reduce the burden of IRI.