Gilles Naeije, Vincent Wens, Mathieu Bourguignon, Serge Goldman, Massimo Pandolfo, Xavier De Tiège, Clinical Neurophysiology, 2019, ISSN 1388-2457, doi:10.1016/j.clinph.2019.05.003.
Evoked responses were detectable in all FRDA patients but one. In patients, TERs were delayed and reduced in amplitude, while AERs were only delayed. Only tactile MMN responses at the contralateral secondary somatosensory cortex were altered in FRDA patients. Maximal amplitudes of TERs, AERs and tactile MMN correlated with genotype, but did not correlate with clinical parameters.
In FRDA, the amplitude of tactile MMN responses at SII cortex are reduced and correlate with the genotype, while auditory MMN responses are not altered. Somatosensory pathways and tactile early change detection are selectively impaired in FRDA.
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