Keeping heart homeostasis in check through the balance of iron metabolism

Driton Vela; Acta Physiol. Accepted Author Manuscript. doi:10.1111/apha.13324

This review is a synthesis of our current knowledge concerning the regulation of cardiac iron metabolism. In addition, different models of cardiac iron dysmetabolism will be discussed through the examples of heart failure (cardiomyocyte iron deficiency), myocardial infarction (acute changes in cardiac iron turnover), doxorubicin induced cardiotoxicity (cardiomyocyte iron overload in mitochondria), thalassemia (cardiomyocyte cytosolic and mitochondrial iron overload), friedreich ataxia (assymetric cytosolic/mitochondrial cardiac iron dysmetabolism). Finally, future perspectives will be discussed in order to resolve actual gaps in knowledge, which should be helpful in finding new treatment possibilities in different cardiac diseases.