Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.

PLoS Biol. 2010 Apr 13;8(4):e1000354.

Rong Shi¹, Ariane Proteau¹, Magda Villarroya², Ismaïl Moukadiri², Linhua Zhang³, Jean-François Trempe¹, Allan Matte³, M. Eugenia Armengod², Miroslaw Cygler^1,3*

1 Department of Biochemistry, McGill University, Montréal, Québec, Canada, 2 Laboratorio de Genética Molecular, Centro de Investigación Príncipe Felipe, Valencia, Spain, 3 Biotechnology Research Institute, Montréal, Québec, Canada

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Highlight: "Our data support the role of frataxin as an iron donor for IscU to form the Fe-S clusters."

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