Mitochondria in cardiac hypertrophy and heart failure

Mitochondria in cardiac hypertrophy and heart failure. Mariana G. Rosca, Bernard Tandler, Charles L. Hoppel. Journal of Molecular and Cellular Cardiology, Volume 55, February 2013, Pages 31-41.

Keywords: Heart failure, Cardiac hypertrophy, Mitochondria, Oxidative phosphorylation

Transition metals and mitochondrial metabolism in the heart

Transition metals and mitochondrial metabolism in the heart. Amy K. Rines, Hossein Ardehali, Journal of Molecular and Cellular Cardiology, Volume 55, February 2013, Pages 50-57. http://dx.doi.org/10.1016/j.yjmcc.2012.05.014

Highlights: "FRDA and doxorubicin toxicities are highlighted as disorders of iron deregulation.", "the heart is one of the most mitochondrially-rich tissues in the body"

The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization

The molecular basis of iron-induced oligomerization of frataxin and the role of the ferroxidation reaction in oligomerization . Christopher A. G. Soderberg, Sreekanth Rajan, Aleksander V. Shkumatov, Oleksandr Gakh, Susanne Schaefer, Eva-Christina Ahlgren, Dmitri I. Svergun, Grazia Isaya and Salam Al-Karadaghi. J. Biol. Chem. jbc.M112.442285. First Published on January 23, 2013, doi:10.1074/jbc.M112.442285

Keywords: Iron-induced oligomerization, frataxin, catalyzed ferroxidation, iron availability, iron delivery.

The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases

The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases.M.E. Breuer, W.J. Koopman, S. Koene, M. Nooteboom, R.J. Rodenburg, P.H. Willems, J.A.M. Smeitink. Neurobiology of Disease, Volume 51, March 2013, Pages 27-34.

Keywords: Mitochondrial dysfunction, Neurodegenerative diseases, Bioenergetics, Cellular metabolism