Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex

PLoS ONE 6(1): e16199. doi:10.1371/journal.pone.0016199

Stéphane Schmucker1,2,3,4,5, Alain Martelli1,2,3,4,5, Florent Colin1,2,3,4,5, Adeline Page1,2,3,4, Marie Wattenhofer-Donzé1,2,3,4,5, Laurence Reutenauer1,2,3,4,5, Hélène Puccio1,2,3,4,5*

1 Department of Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France, 2 Inserm U596, Illkirch, France, 3 CNRS UMR7104, Illkirch, France, 4 Université de Strasbourg, Strasbourg, France, 5 Chaire de Génétique Humaine, Collège de France, Illkirch, France

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Conclusions/Significance

Our results suggest that the interaction of frataxin with the core ISCU/NFS1/ISD11 complex most likely defines the essential function of frataxin. Our results provide new elements important for further understanding the early steps of de novo Fe-S cluster biosynthesis

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The Mitochondrial Connection in Auditory Neuropathy.

Audiol Neurotol 2011;16:398-413 (DOI: 10.1159/000323276)

Cacace AT, Pinheiro JM.
Department of Communication Sciences and Disorders, Wayne State University, Detroit, Mich., USA.

Keywords: Auditory brainstem responses, Auditory neuropathy, Charcot-Marie-Tooth disease, Autosomal dominant optic atrophy, Cochlear microphonics, Friedreich’s ataxia, Hyperbilirubinemia, Respiratory chain, Leber’s hereditary optic neuropathy, Mitochondria, Otoacoustic emissions.

Analysis of nucleosome positioning determined by DNA helix curvature in the human genome

Hongde Liu, Xueye Duan, Shuangxin Yu and Xiao Sun.

BMC Genomics 2011, 12:72doi:10.1186/1471-2164-12-72
Published: 27 January 2011

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