These details support a complex dynamic interaction between the FXN and ISCU proteins when both are part of the NIAUF complex and this provides additional insight into the coordinated mechanism of Fe-S cluster assembly.
Monday, July 5, 2021
Molecular Details of the Frataxin-Scaffold Interaction during Mitochondrial Fe-S Cluster Assembly
Campbell CJ, Pall AE, Naik AR, Thompson LN, Stemmler TL.; Int J Mol Sci. 2021 Jun 2;22(11):6006. doi: 10.3390/ijms22116006.
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