An exploratory qualitative investigation of psychosocial determinants of parental decisions to support sport participation for youth with a mobility impairment

Celina H. Shirazipour, Amy E. Latimer-Cheung, Kelly P. Arbour-Nicitopoulos, Research in Developmental Disabilities, Volumes 45–46, October–November 2015, Pages 400-410, ISSN 0891-4222, http://dx.doi.org/10.1016/j.ridd.2015.08.001.

Compared to parents of non-athletes, parents of athletes identified different, more specific positive outcome expectations, including: being included and family networking. First, while parents of non-athletes viewed inclusion as a social benefit, half of parents of athletes stated that inclusion through sport and being part of the mainstream were important benefits in their own rights, providing distinct outcomes including a sense of normalcy. Second, half of the parents of athletes identified the family benefit of networking with other families. The family network developed within the sport organization provided opportunities to share their enjoyment of their children’s participation, discuss impairment concerns, and gain knowledge from others’ experiences.

Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia

Daman Kumari, Bruce Hayward, Asako J. Nakamura, William M. Bonner, Karen Usdin,Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Available online 30 August 2015, ISSN 0027-5107, http://dx.doi.org/10.1016/j.mrfmmm.2015.08.007.

The region of chromosome 9 that contains the Frataxin (FXN) locus is prone to breakage and rearrangements.This chromosome fragility involves the generation of chromosome/chromatid gaps or breaks, or the high frequency loss of one or both copies of the affected gene when cells are grown under folate stress or as we showed previously, in the presence of an inhibitor of the ATM checkpoint kinase.