Friedreich and dominant ataxias: quantitative differences in cerebellar dysfunction measurements

Tanguy Melac A, Mariotti C, Filipovic Pierucci A on behalf of the EFACTS group, et al; J Neurol Neurosurg Psychiatry Published Online First: 26 December 2017. doi: 10.1136/jnnp-2017-316964

Cerebellar dysfunction, as measured with the CCFS and SARA scales, was more severe in FRDA than in patients with SCA, but with lower progression indexes, within the limits of these types of indexes. Ceiling effects may occur at late stages, for both scales. The CCFS scale is rater-independent and could be used in a multicentre context, as it is simple, rapid and fully automated.