[2Fe-2S]-Ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin

[2Fe-2S]-Ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin. Jin Hae Kim , Ronnie O. Frederick , Nichole M. Reinen , Andrew T. Troupis , and John Lute Markley. J. Am. Chem. Soc., DOI: 10.1021/ja401950a

Keywords: Escherichia coli, [2Fe-2S]-ferredoxin (Fdx), iron-sulfur cluster biogenesis, IscU, and CyaY (bacterial frataxin).

Epigenetic mechanisms governing the process of neurodegeneration

Epigenetic mechanisms governing the process of neurodegeneration. Irfan A. Qureshi, Mark F. Mehler; Molecular Aspects of Medicine, Volume 34, Issue 4, July–August 2013, Pages 875-882. http://dx.doi.org/10.1016/j.mam.2012.06.011

Keywords: Chromatin, Epigenetic, Histone deacetylase, Histone modification, Neurodegenerative disease, Non-coding RNA.

From Mutation Identification to Therapy: Discovery and Origins of the First Approved Gene Therapy in the Western World

From Mutation Identification to Therapy: Discovery and Origins of the First Approved Gene Therapy in the Western World . John J.P. Kastelein, Colin J.D. Ross, and Michael R. Hayden. Human Gene Therapy. May 2013, 24(5): 472-478. doi:10.1089/hum.2013.063.

We hope soon have one similar paper for Friedreich's ataxia ....